Histochemical Studies on Carbonic Anhydrase
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چکیده
منابع مشابه
Infrared studies on the mechanism of action of carbonic anhydrase.
By accurately measuring the difference infrared spectrum of Cot-equilibrated bovine carbonic anhydrase against the ethoxzolamideor azide-inhibited enzyme, we have been able to obtain the absorption maximum at 2341 cm-l that is due to the asymmetric stretching of the CO2 molecule loosely bound to a hydrophobic surface at the active site of the enzyme. COz dissolved in water absorbs at 2343.5 cm-...
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Investigations of the rapid enzyme carbonic anhydrase have now been extended by crystallographic analysis at high CO2 pressures to examine the movements of water molecules in different steps of the catalysis. The rate of catalysis seems well explained by the assembled observations.
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Davenport and Fisher (1938) reported the discovery DOGS P School of Medicine of large amounts of carbonic anhydrase in the gastric mucosa of cats, rats and rabbits. Davenport (1939) demonstrated that carbonic anhydrase is present in high concentration in the parietal cells and in lower concentration in the cells of the surface epithelium of the gastric mucosa of cats and rats. When those invest...
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A library of aromatic/heterocyclic sulfonamides possessing a large diversity of scaffolds has been assayed for inhibition of the carbonic anhydrase (CA, EC 4.2.1.1) from the malaria parasite Plasmodium falciparum (pfCA). Low micromolar and submicromolar in vitro inhibitors were detected, whereas several compounds showed ex vivo anti-P. falciparum activity, in cell cultures. One derivative, that...
متن کامل[Influence of Diamox (acetazolamide sodium) upon inner ear and histochemical study of carbonic anhydrase].
A study was made on the influence of Diamox (acetazolamide sodium) upon inner ear tissue and inner ear fluid, for this drug has been in use for glaucoma for its depressive effect upon the intraocular pressure. On an assumption of the presence of carbonic anhydrase in stria vascularis, widely recognized site of secretion of endolymph, histochemical demonstration of the enzyme was also attempted ...
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ژورنال
عنوان ژورنال: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
سال: 1966
ISSN: 0030-1558,1882-4528
DOI: 10.4044/joma1947.78.6_751